[10] Atlético San Luis 0-0 Cruz Azul [7] 2021-08-22 02:00
Estadio: Estadio Alfonso Lastras Ramirez Round: 6
Árbitro: Oscar Mejia Garcia Home Manager: Marcelo Mendez Away Manager: Juan Maximo Reynoso
Head to Head
| México - Liga MX | 2021/04/24 22:00 | Cruz Azul v Atlético San Luis | L | 3-2 |
| México - Liga MX | 2020/08/24 00:35 | Atlético San Luis v Cruz Azul | L | 1-3 |
| México - Liga MX | 2020/01/18 01:00 | Atlético San Luis v Cruz Azul | W | 2-1 |
| México - Liga MX | 2019/11/24 01:00 | Cruz Azul v Atlético San Luis | L | 3-1 |
Home History
| México - Liga MX | 2021/08/13 02:00 | Atlético San Luis v Necaxa | L | 0-2 |
| México - Liga MX | 2021/08/08 17:00 | Pumas de la UNAM v Atlético San Luis | W | 1-3 |
| México - Liga MX | 2021/08/03 02:00 | Atlético San Luis v Querétaro | D | 1-1 |
| México - Liga MX | 2021/07/25 02:00 | Chivas de Guadalajara v Atlético San Luis | W | 1-2 |
| México - Liga MX | 2021/04/30 02:00 | Atlético San Luis v Pachuca | L | 1-5 |
| México - Liga MX | 2021/04/24 22:00 | Cruz Azul v Atlético San Luis | L | 3-2 |
| México - Liga MX | 2021/04/17 22:00 | Atlético San Luis v Puebla | L | 1-4 |
| México - Liga MX | 2021/04/10 02:30 | Juárez FC v Atlético San Luis | L | 2-1 |
Away History
| México - Liga MX | 2021/08/19 00:00 | Cruz Azul v Monterrey | D | 1-1 |
| México - Liga MX | 2021/08/15 02:00 | Cruz Azul v Toluca | W | 4-0 |
| CONCACAF - Copa de Campeones | 2021/08/12 02:00 | Monterrey v Cruz Azul | L | 1-0 |
| México - Liga MX | 2021/08/07 02:05 | Necaxa v Cruz Azul | W | 1-2 |
| México - Liga MX | 2021/08/01 23:00 | Santos Laguna v Cruz Azul | D | 1-1 |
| México - Liga MX | 2021/07/27 01:00 | Cruz Azul v Mazatlán F.C. | L | 0-2 |
| México - Campeón de Campeones | 2021/07/18 23:30 | León v Cruz Azul | W | 1-2 |
| México - Liga MX | 2021/05/31 01:15 | Cruz Azul v Santos Laguna | D | 1-1 |