[13] Peñarol 5-2 Boston River [15] 2021-05-30 21:00
Estadio: Estadio Campeón del Siglo Round: 3
Árbitro: Christian Ferreyra Home Manager: Jose Mauricio Larriera Away Manager: Juan Ramon Tejera
Head to Head
| Uruguay - Torneo Clausura | 2021/02/07 00:45 | Boston River v Peñarol | W | 1-2 |
| Uruguay - Torneo Intermedio | 2020/11/22 22:30 | Peñarol v Boston River | W | 2-0 |
| Uruguay - Torneo Apertura | 2020/08/16 20:30 | Peñarol v Boston River | W | 2-0 |
| Uruguay - Torneo Clausura | 2019/10/20 21:00 | Peñarol v Boston River | W | 1-0 |
| Uruguay - Torneo Intermedio | 2019/07/14 21:00 | Peñarol v Boston River | W | 4-0 |
| Uruguay - Torneo Apertura | 2019/03/30 22:00 | Boston River v Peñarol | W | 0-4 |
| Uruguay - Torneo Clausura | 2018/08/26 18:00 | Boston River v Peñarol | W | 1-2 |
| Uruguay - Torneo Intermedio | 2018/05/23 23:00 | Peñarol v Boston River | W | 3-0 |
Home History
| Copa Sudamericana | 2021/05/27 00:30 | Sport Huancayo v Peñarol | D | 0-0 |
| Uruguay - Torneo Apertura | 2021/05/22 18:00 | Centro Atlético Fénix v Peñarol | D | 0-0 |
| Copa Sudamericana | 2021/05/18 22:15 | River Plate Asuncion v Peñarol | L | 2-1 |
| Copa Sudamericana | 2021/05/14 00:30 | Peñarol v Corinthians | W | 4-0 |
| Copa Sudamericana | 2021/05/07 00:30 | Peñarol v River Plate Asuncion | W | 3-0 |
| Copa Sudamericana | 2021/04/29 22:15 | Corinthians v Peñarol | W | 0-2 |
| Copa Sudamericana | 2021/04/23 00:30 | Peñarol v Sport Huancayo | W | 5-1 |
| Copa Sudamericana | 2021/04/14 00:30 | Peñarol v Cerro Largo | W | 4-1 |
Away History
| Uruguay - Torneo Apertura | 2021/05/22 15:00 | Boston River v Rentistas | L | 1-2 |
| Uruguay - Torneo Apertura | 2021/05/15 20:15 | Montevideo Wanderers v Boston River | L | 1-0 |
| Uruguay - Torneo Clausura | 2021/03/28 23:00 | Boston River v Liverpool Montevideo | W | 1-0 |
| Uruguay - Torneo Clausura | 2021/03/25 00:15 | Nacional De Football v Boston River | W | 1-2 |
| Uruguay - Torneo Clausura | 2021/03/19 21:15 | Boston River v Danubio | L | 1-5 |
| Uruguay - Torneo Clausura | 2021/03/12 21:45 | Defensor Sporting v Boston River | W | 1-2 |
| Uruguay - Torneo Clausura | 2021/03/06 20:15 | Boston River v Cerro | W | 2-0 |
| Uruguay - Torneo Clausura | 2021/02/28 20:00 | Centro Atlético Fénix v Boston River | L | 2-1 |